The successful applicant will join a pioneering and highly productive project using 3D epithelial tissue and organoid cultures to evaluate small molecule inhibitors of the oncogenic human papillomavirus infection cycle and of HPV-immortalized and transformed tumor equivalents. The research objectives include mechanistic studies of the activation or repression of cell cycle regulatory proteins, epigenetic control of DNA replication and gene expression, and modulation of DNA Damage Response and cell death pathways to identify the most promising targets for novel or repurposed inhibitors of viral persistence and of HPV cancer tissues.
The research involves preparing and maintaining 3D tissue cultures and of treating them with candidate inhibitors over a period of days to weeks before harvest, followed by immunofluorescence imaging as well as Western blot analyses of protein biomarkers, in situ hybridization and visualization of informative nucleic acid sequences, and single cell genomic and proteomic studies. The Fellow will receive substantial professional mentoring from a highly experienced team of faculty, and the investigations are expected to result in high-profile publications and rewarding career development opportunities.
We are looking for a highly motivated candidate with strong training in molecular biology, mammalian cell and tissue culture, isolation of DNA, RNA and proteins from bacteria and/or mammalian cells, quantitative PCR and RT-PCR, immunoblot analysis, flow cytometry, and bioinformatics.
Send a letter of introduction and your biosketch to LTChow@uab.edu, firstname.lastname@example.org, email@example.com.
About our Postdoc Office:
UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The Office of Postdoctoral Education strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.
About the University:
The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has — for more than five decades — produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.
Spanning more than 100 city blocks, UAB is the state of Alabama’s largest single employer with some 25,000 employees and has an annual, state-wide economic impact exceeding $7.15 billion. U.S. News & World Report’s 2020 “America’s Best Graduate Schools” ranks 14 UAB graduate programs among the nation’s top 25 and 10 UAB specialties were ranked among the nation’s top 50 in the magazine’s 2018-2019 Best Hospitals report. UAB research grants and awards are at a record high, exceeding $527 million in FY18, including $320 million in NIH funding for FY18. UAB ranks 31st among all universities in federal research funding and 15th among public universities. UAB's NIH funding continues to grow among peer institutions in the Southeast and beyond, with the university ranking 20th among all universities in NIH funding and eighth among public universities. The UAB School of Medicine is ranked 21st among medical schools in NIH funding and eighth among public medical schools.
UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity, and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.
For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion or call (205) 934-8762. Or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103.